TECHNOLOGY LICENSING OPPORTUNITY: Peptoid-Based Chelating Ligands for Selective Metal Chelation

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Summary from the notice

Peptoid-based chelating ligands offer a tunable platform for capturing and holding specific metal ions with high selectivity while resisting breakdown under physiological conditions. The technology combines structural flexibility with strong binding performance, which creates a practical path for applications where existing chelators fall short, including difficult metal removal in biological, environmental and separation settings. How it Works Peptoid-Based Chelating Ligands uses cyclic peptoid scaffolds, which are peptoid chains closed into ring structures and decorated with side chains chosen for metal binding. By changing the ring size, side-chain chemistry and spacing between binding groups, the ligand can be adjusted to favor certain hard metal ions, especially actinides and lanthanides. Technical Description Peptoids differ from peptides because their side chains attach to nitrogen rather than to carbon, which makes them more resistant to hydrolysis under physiological conditions. That stability matters because many conventional chelators can lose activity in the body or in harsh process streams, while peptoid-based structures are designed to remain intact long enough to bind and hold the target metal. The invention describes cyclic peptoid ligands that can be built from linear peptoids and then cyclized, with the binding profile tuned through functional groups such as catecholates, phosphonates, amines, guanidinium groups, phosphoramidates, N-hydroxypyridones and CMPO…

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