Protein ENGineering (PENG)
| Agency | Department of Defense Defense Advanced Research Projects Agency (darpa) |
| Contracting office | Def Advanced Research Projects Agcy |
| Place of performance | See the notice |
| Type of notice | Open for bids |
| Set-aside | None, open to all businesses |
| Response deadline | Oct 19, 2026 |
| Posted | Aug 21, 2026 |
| Solicitation number | DARPA-PS-26-129 |
| NAICS code | 541714, Research and Development in Biotechnology (except Nanobiotechnology) |
Summary from the notice
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals for the development of a multifunctional, target-agnostic platform for precise, programmable editing of endogenous proteins. The goal of the Protein ENGineering (PENG) program is to transition proteome engineering from a collection of isolated, bespoke tools into a universal, software-defined discipline. The PENG program will establish a comprehensive, integrated platform composed of modular targeting, generalizable effector chemistries, and multiplexed control systems. Rather than developing isolated, target-specific tools, performers will integrate novel splicing, ligation, and co-translational techniques to directly recognize, modify, and rewrite endogenous proteins within complex biological architectures. Performers may explore multiple technical paths, progressively advancing their approaches from foundational validation to robust demonstrations of efficacy. Ultimately, this integrated platform will be validated in high-fidelity cellular models (e.g., organoids), to provide an integrated proof-of-concept at the tissue level.
Other open NAICS 541714 notices
| Deadline | Notice | Set-aside |
|---|---|---|
| Oct 20 Closes today |
Biobanking, Laboratory Analytics, and Associated Informatics Services for NIH Biorepositories
National Institutes of Health Sources sought |
Open to all |
| Oct 20 Closes today |
Biobanking, Laboratory Analytics, and Associated Informatics Services for NIH Biorepositories
National Institutes of Health Sources sought |
Small business |
| Oct 23 3 days left |
Amplicon Sequencing Services
US Geological Survey |
Open to all |
| Oct 30 10 days left |
NAWCWD Broad Agency Announcement
Department of the Navy Special notice |
Open to all |
| Nov 2 13 days left |
DARPA Surgical Competition (DSC) Second Industry Day
Defense Advanced Research Projects Agency (darpa) Special notice |
Open to all |
| Nov 2 13 days left |
NOTICE OF INTENT TO SOLE SOURCE for the Development of a Handheld Device for Rapid Assessment of Burn Sepsis Risk
Defense Health Agency (dha), Silver Spring, MD Special notice |
Open to all |
Details copied from the public SAM.gov notice. BidFox is not connected to SAM.gov or the U.S. Government, so check the official notice before you bid.